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Imaging Core Facility: Molecular Imaging Laboratory

Director: Wang, Paul, Ph.D.

Summary:

The Molecular Imaging Laboratory’s research focuses on small animal in vivo imaging using MRI, and optical fluorescent and bioluminescent imaging. In particular, we are interested in using molecular imaging techniques to study mechanisms of image contrast enhancement, improvement of sensitivity and specificity of tumor detection, and applications of diagnostics using small animal disease models.

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Instruments

  • 7T Bruker MRI ( MRI Scanner )

    7.0 Tesla (21cm bore) Bruker MRI (MRI Scanner)
    A horizontal bore MRI suitable for non-invasive high-resolution imaging of small animals.

  • Bruker 9.4 Tesla (89 mm vertical bore) MRI/MRS ( MRI Scanner )

    A small bore vertical MRI that is suitable for non-invasive imaging of small animals.

  • Perkin Elmer IVIS Spectrum live animal imaging system ( In vivo imaging system ) ( In vivo imaging system )

    "The Perkin Elmer IVIS Spectrum is the most versatile and advanced in vivo imaging system available on the market today. An optimized set of high efficiency filters and spectral un-mixing algorithms lets you take full advantage of bioluminescent and fluorescent reporters across the blue to near infrared wavelength region. It also offers single-view 3D tomography for both fluorescent and bioluminescent reporters that can be analyzed in an anatomical context using our Digital Mouse Atlas.

    For advanced fluorescence imaging, the IVIS Spectrum has the capability to use either trans-illumination (from the bottom) or epi-illumination (from the top) to illuminate in vivo fluorescent sources. 3D diffuse fluorescence tomography can be performed to determine source localization and concentration using the combination of structured light and trans illumination fluorescent images. The instrument is equipped with 10 narrow band excitation filters (30nm bandwidth) and 18 narrow band emission filters (20nm bandwidth) that assist in significantly reducing autofluorescence by the spectral scanning of filters and the use of spectral unmixing algorithms. In addition, the spectral unmixing tools allow the researcher to separate signals from multiple fluorescent reporters within the same animal."

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Last updated: 2013-09-24T14:47:41.205-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016